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. 2012:2012:528079.
doi: 10.5402/2012/528079. Epub 2012 Jul 17.

Osmotic drug delivery system as a part of modified release dosage form

Rajesh A Keraliya  1 , Chirag Patel, Pranav Patel, Vipul Keraliya, Tejal G Soni, Rajnikant C Patel, M M Patel
Affiliations

Osmotic drug delivery system as a part of modified release dosage form

Rajesh A Keraliya et al. ISRN Pharm. 2012.

Abstract

Conventional drug delivery systems are known to provide an immediate release of drug, in which one can not control the release of the drug and can not maintain effective concentration at the target site for longer time. Controlled drug delivery systems offer spatial control over the drug release. Osmotic pumps are most promising systems for controlled drug delivery. These systems are used for both oral administration and implantation. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Osmotic pumps release drug at a rate that is independent of the pH and hydrodynamics of the dissolution medium. The historical development of osmotic systems includes development of the Rose-Nelson pump, the Higuchi-Leeper pumps, the Alzet and Osmet systems, the elementary osmotic pump, and the push-pull system. Recent advances include development of the controlled porosity osmotic pump, and systems based on asymmetric membranes. This paper highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.

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Figures

Figure 1
Figure 1
Plasma concentration profile: for conventional dosage form (- - -) and for controlled release dosage form (—).
Figure 2
Figure 2
Rose Nelson Pump.
Figure 3
Figure 3
Higuchi-Leeper osmotic pump.
Figure 4
Figure 4
Pulsatile release osmotic pump.
Figure 5
Figure 5
Higuchi Theeuwes Pump.
Figure 6
Figure 6
Alzet pump.
Figure 7
Figure 7
The elementary osmotic pump.
Figure 8
Figure 8
The push-pull osmotic pump (PPOP).
Figure 9
Figure 9
Mechanism of action of controlled porosity osmotic pump.
Figure 10
Figure 10
Liquid oral osmotic pump.
Figure 11
Figure 11
Figure of L-OROS system before and during operation.
Figure 12
Figure 12
Figure of sandwiched osmotic pump before and during operation.
See this image and copyright information in PMC

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References

    1. Prescott LF. Novel Drug Delivery and Its Therapeutic application . West Susset, UK: John Wiley and Sons; 1989. The need for improved drug delivery in clinical practice; pp. 1–11.
    1. Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharmaceutical Technology . 2001;25(2):1–14.
    1. Dwarakanadha Reddy P, Swarnalatha D. Recent Advances in Novel Drug Delivery systems. International Journal of PharmTech Research . 2010;2(3):2025–2027.
    1. Rastogi SK, Vaya N, Mishra B. Osmotic pump: a novel concept in rate controlled oral drug delivery. Eastern Pharmacist . 1995;38:79–82.
    1. Banker RW. Control Release of Biologically Active Agent . New York, NY, USA: John Wiley and Son; 1987.