Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Sep;34(9):1806-8.
doi: 10.1128/AAC.34.9.1806.

Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system

P Silley  1 , J W Griffiths, D Monsey, A M Harris
Affiliations
Comparative Study

Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system

P Silley et al. Antimicrob Agents Chemother. 1990 Sep.

Abstract

GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at low concentrations, essentially removing the permeability barrier for antibiotic uptake.

PubMed Disclaimer

References

    1. J Bacteriol. 1980 Jul;143(1):246-55 - PubMed
    1. Antimicrob Agents Chemother. 1987 Apr;31(4):497-504 - PubMed
    1. Eur J Biochem. 1977 Jan;72(2):341-52 - PubMed
    1. Genetics. 1954 Jul;39(4):440-52 - PubMed
    1. Rev Infect Dis. 1981 Nov-Dec;3(6):1127-38 - PubMed

Publication types

MeSH terms