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Clinical Trial
. 1990 Sep;34(9):1809-11.
doi: 10.1128/AAC.34.9.1809.

Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation

T I Ti  1 , E H Monteiro, S Lam, H S Lee
Affiliations
Clinical Trial

Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation

T I Ti et al. Antimicrob Agents Chemother. 1990 Sep.

Abstract

Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.

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References

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    1. Arch Intern Med. 1984 Mar;144(3):533-7 - PubMed
    1. J Pediatr. 1981 Dec;99(6):905-6 - PubMed
    1. J Chromatogr. 1980 Nov 14;221(1):176-81 - PubMed

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