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Review
. 2012 Aug;14(8):777-83.
doi: 10.1038/ncb2548.

Classifying collective cancer cell invasion

Peter Friedl  1 , Joseph Locker, Erik Sahai, Jeffrey E Segall
Affiliations
Review

Classifying collective cancer cell invasion

Peter Friedl et al. Nat Cell Biol. 2012 Aug.

Abstract

Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.

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