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Case Reports
. 2012 Sep;56(5):511-4.
doi: 10.1007/s10384-012-0170-3. Epub 2012 Jul 27.

Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease

Yuka Sogabe  1 , Katsuya Miyatani, Rieko Goto, Gengo Ishii, Koh-Ichi Ohshima, Yasuharu Sato
Affiliations
Case Reports

Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease

Yuka Sogabe et al. Jpn J Ophthalmol. 2012 Sep.

Abstract

Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.

Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.

Conclusion: IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.

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