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Case Reports
. 2012 May;6(2):381-6.
doi: 10.1159/000339713. Epub 2012 Jun 19.

Transient Psychotic Episode Induced by Helicobacter pylori Triple Therapy Treatment

Mitanshu Shah  1 , Miral Subhani, Kaleem Rizvon, Paul Mustacchia
Affiliations
Case Reports

Transient Psychotic Episode Induced by Helicobacter pylori Triple Therapy Treatment

Mitanshu Shah et al. Case Rep Gastroenterol. 2012 May.

Abstract

The term 'antibiomania' refers to manic episodes that occur after a patient starts taking antibiotics. We report the case of a 49-year-old male who developed acute psychosis secondary to initiation of triple therapy for Helicobacter pylori eradication. Unlike with proton pump inhibitors, there have been several reported cases of central nervous system side effects and psychiatric consequences due to amoxicillin, however evidence points to clarithromycin as the likely culprit. On average onset of symptoms occurred within 1-5 days of initiating therapy. In all cases, symptoms resolved upon cessation of clarithromycin, mostly within 1-3 days. Unfortunately, the mechanism through which clarithromycin causes neurotoxicity remains unclear. Clinicians should be cognizant of psychiatric side effects secondary to clarithromycin, and discontinuation should be prompt for rapid recovery of mental status.

Keywords: Helicobacter pylori triple therapy treatment; Transient psychotic episode.

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References

    1. Abouesh A, Stone C, Hobbs WR. Antimicrobial-induced mania (antibiomania): a review of spontaneous reports. J Clin Psychopharmacol. 2002;22:71–81. - PubMed
    1. Sachs G, Shin JM, Howden CW. Review article: the clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 2006;23((suppl 2)):2–8. - PubMed
    1. Delerue O, Muller JP, Destee A, Warot P. Mania-like episodes associated with ranitidine. Am J Psychiatry. 1988;145:271. - PubMed
    1. Beal DM, Hudson B, Zaiac M. Amoxycillin-induced psychosis? Am J Psychiatry. 1986;143:255–256. - PubMed
    1. Bell CL, Watson B, Waring WS. Acute psychosis caused by co-amoxiclav. BMJ. 2008;337:a2117. - PubMed

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