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Clinical Trial
. 1990 Dec 20;37(6):909-15.
doi: 10.1016/0960-0760(90)90442-n.

A randomized double-blind study evaluating Anandron associated with orchiectomy in stage D prostate cancer

M Namer  1 , J Toubol, A Caty, J E Couette, J Douchez, P Kerbrat, J P Droz
Affiliations
Clinical Trial

A randomized double-blind study evaluating Anandron associated with orchiectomy in stage D prostate cancer

M Namer et al. J Steroid Biochem Mol Biol. .

Abstract

A randomized double-blind study with a 3-yr follow-up comparing the two arms "orchiectomy + Anandron (300 mg)" vs "orchiectomy + placebo" in 125 patients with stage D prostate cancer has confirmed the beneficial effects of the combined Anandron therapy on subjective parameters and on the best objective response (NPCP criteria), although these effects were not statistically significant, but failed to detect any improvement in time-to-disease progression or survival. Comparison with the results of other trials emphasizes the urgent need to establish suitable prognostic factors by further clinical research before evaluating the benefits of individual drugs.

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