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Review
. 1990 Jan:4 Suppl 1:7-12.
doi: 10.1007/BF00053420.

Serotonergic antagonists and vascular disease

P M Vanhoutte  1
Affiliations
Review

Serotonergic antagonists and vascular disease

P M Vanhoutte. Cardiovasc Drugs Ther. 1990 Jan.

Abstract

5-Hydroxytryptamine (serotonin) can evoke both contraction and relaxation of vascular smooth muscle. In disease, the constrictor component of the response to the monoamine appears to dominate. 5HT2-serotonergic antagonists favor dilatation, not only because they block the activating effect of serotonin on vascular smooth muscle, but also because they unmask the (endothelium-dependent) relaxation to the monoamine and brake the amplifying effect that it exerts on platelet aggregation. These properties of serotonergic antagonists help to explain their protective effects in vascular disease.

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