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Review
. 2012 Aug;59(4):853-69.
doi: 10.1016/j.pcl.2012.05.020.

Update on the management of disorders of sex development

Rodrigo L P Romao  1 , Joao L Pippi Salle, Diane K Wherrett
Affiliations
Review

Update on the management of disorders of sex development

Rodrigo L P Romao et al. Pediatr Clin North Am. 2012 Aug.

Abstract

A number of factors have contributed to a sharp increase in the number of publications related to disorders of sex development (DSD) in the past 5 years, namely: the establishment of a consensus in 2006 about nomenclature, investigations and the need to treat these patients in a multidisciplinary setting; increase of the knowledge base about genetic mechanisms of normal and abnormal sex development; critical appraisal about the timing and nature of genital surgery in patients with DSD. Herein, the authors present a comprehensive review with up-to-date data about the approach to the newborn with ambiguous genitalia as well as the diagnosis and management of the most common DSD.

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