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. 1979 Sep;16(3):301-5.
doi: 10.1128/AAC.16.3.301.

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound

R J Ash, R A Parker, A C Hagan, G D Mayer

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound

R J Ash et al. Antimicrob Agents Chemother. 1979 Sep.

Abstract

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone) is a new antiviral compound with activity specific for rhinoviruses. Virus synthesis in R-HeLa cells was susceptible to low concentrations (0.25 micrograms/ml) of the compound. RMI 15,731 was effective if added for 1 h before infection and removed or if added as late as 6 h postinfection. Low concentrations of the compound directly inactivated infectious rhinovirus in a time- and temperature-dependent fashion. RMI 15,731 appears to be a promising new antirhinovirus compound for clinical evaluation since it (i) blocks intracellular virus synthesis (without cellular toxicity), and (ii) directly inactivates virions. The last property may be important in limiting virus shedding from an infected host.

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References

    1. Proc Soc Exp Biol Med. 1956 Feb;91(2):305-7 - PubMed
    1. Annu Rev Microbiol. 1972;26:503-24 - PubMed
    1. J Virol. 1967 Jun;1(3):489-93 - PubMed

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