Darwinian evolution and tiding clones in multiple myeloma
- PMID: 22859708
- DOI: 10.1182/blood-2012-06-430645
Darwinian evolution and tiding clones in multiple myeloma
Abstract
In this issue of Blood, Keats et al,(1) Egan et al,(2) and Walker et al(3) provide a genome-wide snapshot of the clonal landscape in multiple myeloma(MM)illustrating the complexity of the evolutionary process and the dynamics of clonal evolution over time.
Comment on
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Clonal competition with alternating dominance in multiple myeloma.Blood. 2012 Aug 2;120(5):1067-76. doi: 10.1182/blood-2012-01-405985. Epub 2012 Apr 12. Blood. 2012. PMID: 22498740 Free PMC article.
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Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides.Blood. 2012 Aug 2;120(5):1060-6. doi: 10.1182/blood-2012-01-405977. Epub 2012 Apr 23. Blood. 2012. PMID: 22529291 Free PMC article.
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Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.Blood. 2012 Aug 2;120(5):1077-86. doi: 10.1182/blood-2012-03-412981. Epub 2012 May 9. Blood. 2012. PMID: 22573403
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