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Review
. 2011 Aug 17;2(8):402-10.
doi: 10.1021/cn200019z. Epub 2011 Mar 22.

Fragile X syndrome: an update on developing treatment modalities

Aileen Healy  1 , Roger Rush, Timothy Ocain
Affiliations
Review

Fragile X syndrome: an update on developing treatment modalities

Aileen Healy et al. ACS Chem Neurosci. .

Abstract

Intellectual disability (ID; mental retardation) is considered an immutable condition. Current medical practices are aimed at relieving symptoms and not at altering the underlying cognitive deficits. Scientific advancements from the past decade have led to the exciting possibility that ID may now be treatable. Moreover, pharmaceutical therapies targeting the most common form of inherited ID, Fragile X syndrome (FXS), may become the new benchmark for central nervous system (CNS) drug discovery: seeking cures for neurodevelopmental disorders.

Keywords: Fragile X syndrome; fragile X mental retardation gene; fragile X mental retardation protein; metabotropic glutamate receptor 5; γ-aminobutyric acid.

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Figures

Figure 1
Figure 1
Structures of prototypical mGluR5 NAMs 1−3, and novel chemotypes 4−14 indicating the company/university that developed them.
See this image and copyright information in PMC

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