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Comment
. 2012 Aug 3;11(2):137-8.
doi: 10.1016/j.stem.2012.07.012.

Adult neurogenesis: VCAM stems the tide

Maria K Lehtinen  1
Affiliations
Comment

Adult neurogenesis: VCAM stems the tide

Maria K Lehtinen. Cell Stem Cell. .

Abstract

In this issue of Cell Stem Cell, Kokovay et al. uncover that VCAM1 expression in neural stem cells regulates adult neurogenesis. Cerebrospinal fluid-borne IL-1β upregulates VCAM1 expression, which in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis.

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Figures

Figure 1
Figure 1. Schematic depicting VCAM1 mediated maintenance of the adult neural stem cell niche
Choroid plexus-secreted IL-1β binds to IL1 receptors on the surface of Type B neural stem cells and upregulates VCAM1 expression. In turn, VCAM1 promotes adhesion to the neural stem cell niche and the pinwheel architecture of ependymal cell rosettes (brown cells) surrounding B cells (green cell) via maintenance of redox homeostasis by NOX2 activation. Inhibition of VCAM1 stimulates quiescent Type B cells to proliferate and advance through the cell lineage to Type A neuroblasts that migrate to the olfactory bulb. Abbreviations: B: Type B neural stem cell; E: Ependymal cell; IL-1β: interleukin 1β; NOX2: NADPH oxidase; ROS: Reactive oxygen species; VCAM1: vascular cell adhesion molecule-1; V-SVZ: Ventricular-subventricular zone.
See this image and copyright information in PMC

Comment on

References

    1. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47–95. - PubMed
    1. Fuentealba LC, Obernier K, Alvarez-Buylla A. Adult neural stem cells bridge their niche. Cell Stem Cell. 2012;10:698–708. - PMC - PubMed
    1. Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y, Roysam B, Shen Q, Temple S. Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell. 2010;7:163–173. - PMC - PubMed
    1. Kokovay E, Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q, Temple S. VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression. Cell Stem Cell. 2012 In this issue. - PubMed
    1. Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell. 2011;8:59–71. - PMC - PubMed

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