Greasing the way: the ABCs of HSPC efflux from the marrow
- PMID: 22862939
- PMCID: PMC3429340
- DOI: 10.1016/j.stem.2012.07.009
Greasing the way: the ABCs of HSPC efflux from the marrow
Abstract
In this issue of Cell Stem Cell, Westerterp et al. demonstrate that cholesterol flux through splenic phagocytes regulates hematopoietic stem and multipotential progenitor cell mobilization from the bone marrow. These exciting findings suggest new avenues for therapy of myeloproliferative disorders and atherosclerosis.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways.Cell Stem Cell. 2012 Aug 3;11(2):195-206. doi: 10.1016/j.stem.2012.04.024. Cell Stem Cell. 2012. PMID: 22862945 Free PMC article.
References
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- Gomes AL, Carvalho T, Serpa J, Torre C, Dias S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. Blood. 2010;115:3886–3894. - PubMed
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