Exposing secrets of telomere-telomerase encounters
- PMID: 22863000
- DOI: 10.1016/j.cell.2012.07.015
Exposing secrets of telomere-telomerase encounters
Erratum in
- Cell. 2012 Aug 31;150(5):1082
Abstract
In order for telomeres to remain functional and stable, they must rendezvous with the enzyme telomerase in a productive manner. In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.Cell. 2012 Aug 3;150(3):481-94. doi: 10.1016/j.cell.2012.07.012. Cell. 2012. PMID: 22863003 Free PMC article.
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