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. 2012;35(8):1213-5.
doi: 10.1248/bpb.b12-00378.

New cancer immunotherapy using autologous lymphocytes activated with trastuzumab

Shinichirou Nakagawa  1 , Yusuke Matsuoka, Hideaki Ichihara, Hitoji Yoshida, Kenshi Yoshida, Ryuichi Ueoka
Affiliations
Free article

New cancer immunotherapy using autologous lymphocytes activated with trastuzumab

Shinichirou Nakagawa et al. Biol Pharm Bull. 2012.
Free article

Abstract

It is well known that trastuzumab (TTZ) is molecular target drug for breast cancer overexpressing human epidermal growth factor receptor 2 (HER2). Novel immunotherapy by human peripheral blood mononuclear cells (PBMCs) activated with TTZ were examined. Proliferation of lymphocytes after adding of TTZ was obtained. Furthermore, lymphocytes activated with TTZ inhibited growth of breast cancer cells in vitro. It is noteworthy that remarkably high cellular cytotoxicity in lymphocytes activated with TTZ compared with that of CD3- and lymphokine (interleukin (IL)2)-activated killer (CD3-LAK) cells commonly used in immunotherapy were revealed.

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