Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Oct;55(10):2559-2561.
doi: 10.1007/s00125-012-2659-1. Epub 2012 Aug 5.

Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men

E Renström  1
Affiliations
Comment

Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men

E Renström. Diabetologia. 2012 Oct.

Abstract

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

PubMed Disclaimer

Comment on

References

    1. Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320–323. doi: 10.1038/ng1732. - DOI - PubMed
    1. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331–1336. doi: 10.1126/science.1142358. - DOI - PubMed
    1. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445:881–885. doi: 10.1038/nature05616. - DOI - PubMed
    1. Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia. 2007;50:1–4. doi: 10.1007/s00125-006-0507-x. - DOI - PMC - PubMed
    1. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316:1336–1341. doi: 10.1126/science.1142364. - DOI - PMC - PubMed

Publication types

MeSH terms