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. 2012 Sep;8(9):748-50.
doi: 10.1038/nchembio.1043. Epub 2012 Aug 5.

Expanding the genetic code of Drosophila melanogaster

Ambra Bianco  1 , Fiona M Townsley, Sebastian Greiss, Kathrin Lang, Jason W Chin
Affiliations

Expanding the genetic code of Drosophila melanogaster

Ambra Bianco et al. Nat Chem Biol. 2012 Sep.

Abstract

Genetic code expansion for unnatural amino acid mutagenesis has, until recently, been limited to cell culture. We demonstrate the site-specific incorporation of unnatural amino acids into proteins in Drosophila melanogaster at different developmental stages, in specific tissues and in a subset of cells within a tissue. This approach provides a foundation for probing and controlling processes in this established metazoan model organism with a new level of molecular precision.

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