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Review
. 2013 Jan;17(1):127-41.
doi: 10.1007/s10461-012-0272-4.

MACH14: a multi-site collaboration on ART adherence among 14 institutions

Honghu Liu  1 , Ira B Wilson, Kathy Goggin, Nancy Reynolds, Jane M Simoni, Carol E Golin, Marc I Rosen, Robert Gross, Glenn Wagner, Robert H Remien, Neil Schneiderman, Judith A Erlen, Julia H Arnsten, David R Bangsberg
Affiliations
Review

MACH14: a multi-site collaboration on ART adherence among 14 institutions

Honghu Liu et al. AIDS Behav. 2013 Jan.

Abstract

The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

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Figures

Fig. 1
Fig. 1
Overall adherence of 16 studies by month
See this image and copyright information in PMC

References

    1. Feeney ER, Mallon PWG. HIV and HAART-associated dyslipidemia. Open Cardiovasc Med J. 2011;5:49–63. - PMC - PubMed
    1. Enanoria WTA, Ng C, Saha SR, Colford JM., Jr Treatment outcomes after highly active antiretroviral therapy: a meta-analysis of randomised controlled trials. Lancet Infect Dis. 2004;4(7):414–25. - PubMed
    1. Bhaskaran K, Hamouda O, Sannes M, et al. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMA. 2008;300(1):51–9. - PubMed
    1. Bangsberg DR, Hecht FM, Charlebois ED, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS. 2000;14(4):357–66. - PubMed
    1. Lucas GM. Antiretroviral adherence, drug resistance, viral fitness and HIV disease progression: a tangled web is woven. J Anti-microb Chemother. 2005;55(4):413–6. - PubMed

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