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Comment
. 2012:8:598.
doi: 10.1038/msb.2012.33.

Cells, shared memory and breaking the PTM code

Pau Creixell, Rune Linding
Comment

Cells, shared memory and breaking the PTM code

Pau Creixell et al. Mol Syst Biol. 2012.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Post-translational regulatory centers and co-evolution of PTMs. (A) The interplay between PTMs (represented as dashed lines) and their location in post-transcriptional regulatory centers is a key feature that would facilitate an explosion of the degree of regulation and number of functional states that a protein can reach by combining multiple PTM-driven logic gates. The timing and order of events (represented by one number for each writer and reader domain) would be crucial to determine cellular outcome. (B) Co-evolution between different PTMs is represented as a network where line strength indicates degree of co-evolution and color denote location preference of the respective proteins.
See this image and copyright information in PMC

Comment on

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