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. 2012 Oct;31(10):1123-7.
doi: 10.1097/ICO.0b013e31825694d3.

Seasonal trends of microbial keratitis in South India

Charles C Lin  1 , Prajna Lalitha, Muthiah Srinivasan, N Venkatesh Prajna, Stephen D McLeod, Nisha R Acharya, Thomas M Lietman, Travis C Porco
Affiliations

Seasonal trends of microbial keratitis in South India

Charles C Lin et al. Cornea. 2012 Oct.

Abstract

Purpose: Previous studies suggest that fungal keratitis is more common in hot humid climates and that bacterial keratitis is independent of seasonal variation. This study analyzes seasonal trends in the incidence of fungal and bacterial keratitis at the Aravind Eye Hospital in southeast India.

Methods: Using microbiology records from August 2006 to July 2009, retrospective analyses of infectious keratitis were performed. Bacterial and fungal keratitis incidence data were analyzed for seasonal patterns.

Results: Among the 6967 infectious keratitis cases, cultures were performed in 5221 (74.9%) cases; among them, 3028 (58%) were positive. Of the culture-positive cases, 1908 (63%) and 1081 (35.7%) were of fungal and bacterial etiology, respectively. The predominant fungal organism was Fusarium spp (42.3%) and the predominant bacterial organisms were Streptococcus pneumoniae (35.1%), Pseudomonas aeruginosa (24.3%), and Nocardia spp (8.1%). Analyses revealed an uneven distribution of fungal keratitis throughout the year (P < 0.001) with peaks in July and January. No significant seasonal trend was observed for the combined bacterial keratitis group.

Conclusions: A higher incidence of fungal keratitis occurs during the months corresponding to the windy and harvest seasons, during which time infection from vegetative corneal injury may be more likely. Robust screening efforts during these periods may mitigate visually debilitating sequelae from infectious keratitis.

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Figures

Figure 1
Figure 1
Smoothed plot of the number of culture-confirmed infectious keratitis cases due to fungal, bacterial, and Acanthamoeba spp for each day of the year between August 1, 2006 and July 31, 2009, Aravind Eye Hospital.
Figure 2
Figure 2
Smoothed plot of the number of culture-confirmed infectious keratitis cases due to all fungal and Fusarium spp between August 1, 2006 and July 31, 2009, Aravind Eye Hospital.
Figure 3
Figure 3
Smoothed plot of the number of culture-confirmed infectious keratitis cases due to all bacteria, Streptococcus pneumoniae, Nocardia spp, and Pseudomonas spp between August 1, 2006 and July 31, 2009, Aravind Eye Hospital.
See this image and copyright information in PMC

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