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. 2012 Jul;28(3):314-7.
doi: 10.4103/0970-9185.98322.

Injection pain of propofol in children: A comparison of two formulations without added lidocaine

Serbülent Gökhan Beyaz  1 , Ali Eman
Affiliations

Injection pain of propofol in children: A comparison of two formulations without added lidocaine

Serbülent Gökhan Beyaz et al. J Anaesthesiol Clin Pharmacol. 2012 Jul.

Abstract

Background: Propofol emulsion in medium and long-chain triglycerides (MCT/LCT) has been reported to cause less injection pain than other propofol solutions in adult studies. The aim of this study was to compare the injection pain of two different propofol emulsions using two different pain scales on the pediatric population.

Materials and methods: 100 children scheduled for general anesthesia were divided into two groups. Patients were randomly assigned to receive propofol LCT or propofol MCT/LCT. Assessment and evaluation of the Ontario Children's Hospital Pain Scale (mCHEOPS) and the Wong-Baker Faces Scale (WBFS) were performed at the start of the injection until the patients lose consciousness.

Results: There were no significant differences between groups in terms of demographic data. According to the mCHEOPS scale, the pain incidence of propofol LCT was 5%, whereas for propofol MCT/LCT it was 15% (P < 0.05). According to the WBFS Pain Scale, the pain incidence of propofol LCT was 17%, whereas for propofol MCT/LCT it was 21% (P > 0.05).

Conclusions: Propofol MCT/LCT does not decrease injection pain; contrary to the general assumption, it causes more pain than propofol LCT in children.

Keywords: Children; injection pain; intravenous anesthetics; propofol.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

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Figure 1
Postcancrum oris defect
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References

    1. Cox RG. Are children just little adults when it comes to propofol injection pain? Can J Anaesth. 2002;49:1016–20. - PubMed
    1. Rochette A, Hocquet AF, Dadure C, Boufroukh D, Raux O, Lubrano JF, et al. Avoiding propofol injection pain in children: A prospective, randomized, double-blinded, placebo-controlled study. Br J Anaesth. 2008;101:390–4. - PubMed
    1. Rahman Al-Refai A, Al-Mujadi H, Petrova Ivanova M, Marzouk HM, Batra YK, Al-Qattan AR. Prevention of pain on injection of propofol: A comparison of remifentanil with alfentanil in children. Minerva Anestesiol. 2007;73:219–23. - PubMed
    1. Beh T, Splinter W, Kim J. In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. Can J Anaesth. 2002;49:1061–3. - PubMed
    1. Kwak HJ, Min SK, Kim JS, Kim JY. Prevention of propofol-induced pain in children: Combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. Br J Anaesth. 2009;103:410–2. - PubMed