Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;5(1):32-6.
doi: 10.4103/0974-1208.97795.

Prediction of ovarian hyperstimulation syndrome in coasted patients in an IVF/ICSI program

Fatimah Y Aljawoan  1 , Linda P Hunt, Uma D Gordon
Affiliations

Prediction of ovarian hyperstimulation syndrome in coasted patients in an IVF/ICSI program

Fatimah Y Aljawoan et al. J Hum Reprod Sci. 2012 Jan.

Abstract

Aim: To determine why a subgroup of coasted patients developed moderate/severe ovarian hyperstimulation syndrome (OHSS) in an assisted reproduction setting.

Materials and methods: Retrospective study of 2948 in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles with 327 patients requiring coasting. Long protocol gonadotrophin releasing hormone analogue (GnRH-a) regimen was used and serum estradiol (E(2)) checked when ≥20 follicles were noted on follicular tracking. Coasting was initiated when leading three follicles were ≥15mm with E(2) ≥1635pg/ml.

Results: The incidence of moderate/severe OHSS was 10.4% in coasted patients (equivalent 1.15% of the total IVF/ICSI cycles in the Center). Coasted patients who subsequently developed OHSS showed a significantly higher number of retrieved oocytes, higher serum E(2) level on the day of human chorionic gonadotrophin (hCG) administration, and multiple pregnancies. No significant differences were noted with female age, BMI, cause of infertility, gonadotrophin dosage, coasting duration, and % of E(2) drop.

Conclusion: Moderate/severe OHSS might be predicted in coasted patients by a combination of total oocyte numbers and E(2) level on the day of hCG. Multiple pregnancies also significantly increased the risk.

Keywords: Coasted patients; IVF treatment cycle; ovarian hyperstimulation syndrome.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Garcia-Velasco JA, Zuniga A, Pacheco A, Gomez R, Simon C, Remohi J, et al. Coasting acts through downregulation of VEGF gene expression and protein secretion. Hum Reprod. 2004;19:1530–8. - PubMed
    1. Mathur R, Evbuomwan I, Jenkins J. Prevention and management of ovarian hyperstimulation syndrome. Curr Obstet Gynacol. 2000;12:111–6.
    1. Abulghar MA, Mansour RT. Ovarian hyperstimulation syndrome: Classifications and critical analysis of preventive measures. Hum Reprod Update. 2003;9:275–89. - PubMed
    1. Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): A review. Hum Reprod. 2002;8:559–77. - PubMed
    1. Asch RH, Li HP, Balmaceda JP, Weckstein LN, Stone SC. Severe ovarian hyperstimulation syndrome in assisted reproductive technology: Definition of high risk groups. Hum Reprod. 1991;10:1395–9. - PubMed