Effect of a target-controlled infusion of remifentanil in combination with desflurane during the "maintenance" phase of general anesthesia

Abstract

Background: The goal of this study was to determine the optimal target-controlled concentration of remifentanil combined with desflurane, by using a more widely and decreasing end-tidal concentration of desflurane.

Methods: Ninety ASA I patients, who underwent general anesthesia for elective orthopedic or extremity surgeries, were registered and randomly allocated to receive either a target-controlled concentration of 1 ng/ml (group R1), 2 ng/ml (group R2) remifentanil, or desflurane only without remifentanil infusion (group D). Mean arterial pressure (MAP) and heart rate (HR) were recorded at 5-min intervals from after a 10-15 min period of surgical incision to before a 10-min period prior to the end of an operation. End-tidal concentration of desflurane was increased or decreased in proportion to the changes in MAP and HR. If the value of bispectral index (BIS) was from 60-62 for more than 2 min or systolic blood pressure would fall below 90 mmHg, the patient was excluded from the study to prevent a risk of "explicit awareness" and shock.

Results: The end-tidal desflurane concentration was lower in the group receiving 1 ng/ml (5.2 ± 0.5 vol%; P < 0.001) and 2 ng/ml remifenanil (4.4 ± 0.5 vol%; P < 0.001) compared to patients in group D (7.9 ± 0.5 vol%).

Conclusions: We recommend the use of 2 ng/ml or less remifentanil combined with desflurane for decreasing concentrations of desflurane without significant side effects, during the "maintenance" phase, and not during the induction phase of general anesthesia.

Keywords: Desflurane; Remifentanil; Target-controlled infusion.

Fig. 1

End-tidal concentration of desflurane. Values are mean ± SE at 5-min intervals during MGA. Group R1: patients received a 1 ng/ml effect-site target-controlled concentration of remifentanil with desflurane, Group R2: patients received a 2 ng/ml effect-site target-controlled concentration of remifentanil with desflurane, Group D: patients received desflurane only without remifentanil infusion. ETCdes: End-tidal concentration of desflurane (vol%). ^*P < 0.05 compared with group R1. ^†P < 0.001 compared with group D.