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. 2012 Jul 5;2 Suppl 1(Suppl 1):S2.
doi: 10.1186/2110-5820-2-S1-S2. Epub 2012 Jul 5.

Intra-abdominal hypertension in patients with sellar region tumors

Konstantin A Popugaev  1 , Ivan A Savin, Andrew U Lubnin, Alexander S Goriachev, Boris A Kadashev, Pavel L Kalinin, Andrew V Oshorov, Alexander A Polupan, Ekaterina U Sokolova, Maxim A Kutin, Valeriy I Lukianov
Affiliations

Intra-abdominal hypertension in patients with sellar region tumors

Konstantin A Popugaev et al. Ann Intensive Care. .

Abstract

Background: Data on intra-abdominal hypertension [IAH] and secondary abdominal compartment syndrome [ACS] due to neurological insults are limited.

Methods: This was a prospective observational study conducted between January 2010 and January 2011 in the neurological ICU [NICU]. Forty-one consecutive patients with sellar region tumors [SRT] were enrolled into the study. If conservative therapy was ineffective in patients with ACS, thoracic epidural anesthesia [EA] was performed. Primary endpoint was defined as the efficacy of conservative treatment and EA in patients with IAH and ACS; secondary endpoint, the influence of IAH and ACS on outcomes.

Results: Of the 41 patients, 13 (31.7%) had normal intra-abdominal pressure and 28 (68.3%) developed IAH, of whom 9 (22%) had ACS (group II). On average, IAH developed on the second postoperative day, while ACS, between the third and the fifth day. Multiple organ dysfunction developed in 3 (23.1%) patients of group I and in 23 (82%) patients of group II (p = 0.0003). Ileus due to gastrointestinal dysmotility was present in 6 (46.2%) patients of group I and in all patients of group II (p = 0.0001). Significant risk factors for ileus were diencephalon dysfunction (whole group - in 33 patients (80.5%); group I - in 6 patients (46.2%); group II - in 27 patients (96.4%), p = 0.0002) and sepsis (whole group - in 8 patients (19.5%); group I - no cases; group II - in 8 patients (28.6%), p = 0.03). Conservative treatment was effective in the majority of patients (78.9%) with IAH and only in 3 (33%) patients with ACS. Thoracic EA was performed in four patients with ACS with success. Length of stay in the NICU was 6.5 ± 4.6 days in group I and 24.1 ± 25.7 (p = 0.02) days in group II. Five out of nine (55.6%) patients with ACS died. None of these patients received EA. All patients with EA had favorable outcomes.

Conclusion: The development of IAH is common after SRT surgery. If conservative treatment is ineffective, EA can be considered in patients with secondary ACS. Further studies are warranted.

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Figures

Figure 1
Figure 1
Mean IAP in groups I and II during the first seven days of postoperative period.
Figure 2
Figure 2
Mean IAP in survivors and non-survivors during the first seven days of postoperative period.
See this image and copyright information in PMC

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