The influence of stress on convulsive parameters in the mouse

Abstract

Mice exposed to the stress of conspecific aggression for 10 min showed shorter latencies to convulsions induced by pentylenetetrazol but not by pilocarpine. This effect was short lived and was not influenced by pretreatment with naltrexone (5 mg/kg, SC). The onset of pilocarpine-induced convulsions in stressed mice was reduced by the opioid antagonist. Aggression stress did not change the incidence, duration or severity of convulsions triggered by the chemoconvulsants or electroshock. The results differ widely from those obtained using other stressogenic models such as cold-restraint or swim stress. This suggests that alterations of convulsive parameters and the involvement of opioid mechanisms in their mediation are critically dependent on the characteristics of the stressogenic procedure employed.