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. 2012 Sep 7;14(17):4478-81.
doi: 10.1021/ol301980g. Epub 2012 Aug 9.

Facile, selective, and regiocontrolled synthesis of oxazolines and oxazoles mediated by ZnI2 and FeCl3

Gopal Chandru Senadi  1 , Wan-Ping Hu, Jia-Shing Hsiao, Jaya Kishore Vandavasi, Chung-Yu Chen, Jeh-Jeng Wang
Affiliations

Facile, selective, and regiocontrolled synthesis of oxazolines and oxazoles mediated by ZnI2 and FeCl3

Gopal Chandru Senadi et al. Org Lett. .

Abstract

An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI(2) and FeCl(3) is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.

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