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. 2013 May;141(5):1009-20.
doi: 10.1017/S0950268812001665. Epub 2012 Aug 9.

Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden

M Insulander  1 , C Silverlås, M Lebbad, L Karlsson, J G Mattsson, B Svenungsson
Affiliations

Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden

M Insulander et al. Epidemiol Infect. 2013 May.

Abstract

This study describes the epidemiology and symptoms in 271 cryptosporidiosis patients in Stockholm County, Sweden. Species/genotypes were determined by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) of the Cryptosporidium oocyst wall protein (COWP) and 18S rRNA genes. Species were C. parvum (n=111), C. hominis (n=65), C. meleagridis (n=11), C. felis (n=2), Cryptosporidium chipmunk genotype 1 (n=2), and a recently described species, C. viatorum (n=2). Analysis of the Gp60 gene revealed five C. hominis allele families (Ia, Ib, Id, Ie, If), and four C. parvum allele families (IIa, IIc, IId, IIe). Most C. parvum cases (51%) were infected in Sweden, as opposed to C. hominis cases (26%). Clinical manifestations differed slightly by species. Diarrhoea lasted longer in C. parvum cases compared to C. hominis and C. meleagridis cases. At follow-up 25-36 months after disease onset, 15% of the patients still reported intermittent diarrhoea. In four outbreaks and 13 family clusters, a single subtype was identified, indicating a common infection source, which emphasizes the value of genotyping for epidemiological investigations.

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Figures

Fig. 1.
Fig. 1.
Age distribution of Cryptosporidium parvum and Cryptosporidium hominis cases, diagnosed in Stockholm County during the study period, April 2006 to November 2008.
Fig. 2.
Fig. 2.
Monthly distribution of Cryptosporidium parvum and Cryptosporidium hominis cases diagnosed in Stockholm County during the study period, April 2006 to November 2008. The five outbreaks are described in the text.
See this image and copyright information in PMC

References

    1. Fayer R. General biology. In Fayer R, Xiao L, eds. Cryptosporidium and Cryptosporidiosis, 2nd edn. Boca Raton: CRC Press, 2008, pp. 1–42.
    1. Fayer R, Santin M, Macarisin D. Cryptosporidium ubiquitum n.sp. in animals and humans. Veterinary Parasitology 2011; 172: 23–32. - PubMed
    1. Fayer R, Santin M. Cryptosporidium xiaoi n.sp. (Apicomplexa: Cryptosporidiidae) in sheep (Ovis aries). Veterinary Parasitology 2009; 164: 192–200. - PubMed
    1. Plutzer J, Karanis P. Genetic polymorphism in Cryptosporidium species: an update. Veterinary Parasitology 2009; 165: 187–199. - PubMed
    1. Ren X, et al. Cryptosporidium tyzzeri n.sp. (Apicomplexa: Cryptosporidiidae) in domestic mice (Mus musculus). Experimental Parasitology. Published online 23 July 2011. doi:10.1016/j.exppara.2011.07.012. - DOI - PubMed

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