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Comment
. 2012 Aug 10;337(6095):646; author reply 646.
doi: 10.1126/science.1222519.

Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition"

Stefan Löffler  1 , Jochen Körber, Udo Nubbemeyer, Karin Fehsel
Affiliations
Comment

Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition"

Stefan Löffler et al. Science. .

Abstract

Ray et al. (Reports, 29 July 2011, p. 637) assume that clozapine-N4-oxide (CNO) represents a "biologically inert synthetic ligand" that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects.

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