Autologous T cells on the attack against AML
- PMID: 22879624
- DOI: 10.1182/blood-2012-06-433177
Autologous T cells on the attack against AML
Abstract
In this issue of Blood, Greiner and colleagues describe how peptides derived from the mutated nucleophosmin 1 gene (NPM1(mut)) can elicit in vitro CD4(+) and CD8(+) T-cell responses in patients with acute myeloid leukemia, which can lead to antigen-specific lysis of leukemic blasts.
Comment on
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Mutated regions of nucleophosmin 1 elicit both CD4(+) and CD8(+) T-cell responses in patients with acute myeloid leukemia.Blood. 2012 Aug 9;120(6):1282-9. doi: 10.1182/blood-2011-11-394395. Epub 2012 May 16. Blood. 2012. PMID: 22592607
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