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. 2012 Aug;5(4):311-3.
doi: 10.1111/j.1752-8062.2012.00440.x.

CTSA-enhanced innovative device development

Marco Bisoffi  1 , Virginia Severns, Richard Larson
Affiliations

CTSA-enhanced innovative device development

Marco Bisoffi et al. Clin Transl Sci. 2012 Aug.
No abstract available

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Figures

Figure 1
Figure 1
(A) Portable set up of biosensor. Detection board (thin arrow) with fluidic chamber (sensor chip is inside [asterisk]), and PDA (thick arrow) and battery (arrowhead) are shown. (B) Functionalization of biosensor surface consisting of the piezoelectric lithium tantalate (LiTaO3), silicon oxide (SiO2), and silane to bind specific ligands, including monoclonal antibodies, nucleic acids, and peptides. (C) Detection of F. tularensis using a monoclonal antibody against surface lipopolysaccharide (LPS). Quadruplicate measurements (mean ± standard deviation) were taken at 5 minutes after addition of bacteria. The x‐axis and y‐axis indicate viral load (logarithmic scale; CFU = colony forming units) and phase shifts (Δϕ), respectively. The solid line represents the best‐fitting model and coefficient correlations (R2) for Δϕ as a function of bacterial load. The horizontal dotted line represents the background signal obtained with buffer without bacteria.
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