Finally, polyubiquitinated PCNA gets recognized
- PMID: 22883622
- DOI: 10.1016/j.molcel.2012.07.024
Finally, polyubiquitinated PCNA gets recognized
Abstract
Studies from Ciccia et al. (2012) and Yuan et al. (2012) in this issue of Molecular Cell, together with Weston et al. (2012), reveal that the translocase ZRANB3/AH2 can recognize K63-linked polyubiquitinated PCNA and plays an important role in restarting stalled replication forks.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.Mol Cell. 2012 Aug 10;47(3):396-409. doi: 10.1016/j.molcel.2012.05.024. Epub 2012 Jun 14. Mol Cell. 2012. PMID: 22704558 Free PMC article.
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The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.Mol Cell. 2012 Aug 10;47(3):410-21. doi: 10.1016/j.molcel.2012.05.025. Epub 2012 Jun 14. Mol Cell. 2012. PMID: 22705370 Free PMC article.
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ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.Genes Dev. 2012 Jul 15;26(14):1558-72. doi: 10.1101/gad.193516.112. Epub 2012 Jul 3. Genes Dev. 2012. PMID: 22759634 Free PMC article.
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