Themes and variations of viral small terminase proteins
- PMID: 22884105
- PMCID: PMC3419939
- DOI: 10.1016/j.str.2012.07.007
Themes and variations of viral small terminase proteins
Abstract
Viruses are the most populous ‘biological entities’ on Earth (Krupovic and Bamford, 2011). The most common of these are the tailed, double-stranded DNA (dsDNA) containing bacteriophages, which outnumber bacteria by 10 fold. Since they do number so many, bacteriphages greatly affect global processes (Suttle, 2007). Related to dsDNA phages are the eukaryotic dsDNA Herpesviruses, which cause a host of diseases including chicken pox, shingles, Karposi’s sarcoma and mononucleosis (Cardone et al., 2012). Thus, understanding the assembly of this class of viruses is important for both the global climate and human health.
Comment on
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Small terminase couples viral DNA binding to genome-packaging ATPase activity.Structure. 2012 Aug 8;20(8):1403-13. doi: 10.1016/j.str.2012.05.014. Epub 2012 Jul 5. Structure. 2012. PMID: 22771211 Free PMC article.
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