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Comment
. 2012 Aug;2(8):673-5.
doi: 10.1158/2159-8290.CD-12-0311.

Turn off the IDO: will clinical trials be successful?

Sergey V Novitskiy  1 , Harold L Moses
Affiliations
Comment

Turn off the IDO: will clinical trials be successful?

Sergey V Novitskiy et al. Cancer Discov. 2012 Aug.

Abstract

Indoleamine 2,3-dioxygenase (IDO) is overexpressed in many human cancers and is believed to play a role in tumor immune evasion, but a requirement for IDO in tumor progression has not been formally shown. The study by Smith and colleagues in this issue of Cancer Discovery provides genetic evidence for the importance of IDO in tumorigenesis, which supports the use of IDO inhibitors in clinical trials in humans.

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  • IDO is a nodal pathogenic driver of lung cancer and metastasis development.
    Smith C, Chang MY, Parker KH, Beury DW, DuHadaway JB, Flick HE, Boulden J, Sutanto-Ward E, Soler AP, Laury-Kleintop LD, Mandik-Nayak L, Metz R, Ostrand-Rosenberg S, Prendergast GC, Muller AJ. Smith C, et al. Cancer Discov. 2012 Aug;2(8):722-35. doi: 10.1158/2159-8290.CD-12-0014. Epub 2012 Jul 19. Cancer Discov. 2012. PMID: 22822050 Free PMC article.

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