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. 2012:2012:837958.
doi: 10.1155/2012/837958. Epub 2012 Jul 24.

Comparison of the Effects on Rib Fracture between the Traditional Japanese Medicine Jidabokuippo and Nonsteroidal Anti-Inflammatory Drugs: A Randomized Controlled Trial

Hajime Nakae  1 , Aya Yokoi, Hiroyuki Kodama, Akira Horikawa
Affiliations

Comparison of the Effects on Rib Fracture between the Traditional Japanese Medicine Jidabokuippo and Nonsteroidal Anti-Inflammatory Drugs: A Randomized Controlled Trial

Hajime Nakae et al. Evid Based Complement Alternat Med. 2012.

Abstract

Jidabokuippo is a traditional Japanese medicine used for contusion-induced swelling and pain. This open multicenter randomized study was designed to compare the efficacies of jidabokuippo and nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rib fracture by analyzing the treatment duration. Our study involved 170 rib fracture patients capable of oral ingestion divided randomly into 2 groups: the jidabokuippo and NSAID groups. We compared the duration of treatment and healthcare expenditure between these 2 groups. Medication was continued in both groups until the visual analogue scale score decreased to less than 50% of the pretreatment score. We excluded the patients in whom medication was prematurely discontinued. We analyzed 81 patients belonging to the jidabokuippo and NSAIDs groups. No significant intergroup differences were observed in age, gender, severity (injury severity score), and presence/absence of underlying disease. The treatment duration was significantly shorter in the jidabokuippo group than in the NSAIDs group (P = 0.0003). Healthcare expenditure was significantly lower in the jidabokuippo group than in the NSAIDs group (P < 0.0001). Our results suggest that compared to NSAIDs, jidabokuippo can shorten the duration of treatment in patients with rib fracture and is a promising analgesic agent based on the medical economic viewpoint.

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Figures

Figure 1
Figure 1
Three-dimensional high-performance liquid chromatography (HPLC) profile of jidabokuippo.
Figure 2
Figure 2
Study flow diagram.
Figure 3
Figure 3
Comparison of treatment durations between the jidabokuippo and the NSAIDs groups. Median treatment duration was significantly lower in the jidabokuippo group than in the NSAIDs group (P < 0.001).
See this image and copyright information in PMC

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