Neurodegenerative disease: Microglia in early disease stages

Comment

Katie Kingwell. Nat Rev Neurol. 2012 Sep.

. 2012 Sep;8(9):475.

doi: 10.1038/nrneurol.2012.172. Epub 2012 Aug 14.

No abstract available

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Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.
Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. J Neurosci. 2012 Jul 25;32(30):10201-10. doi: 10.1523/JNEUROSCI.1496-12.2012. J Neurosci. 2012. PMID: 22836255 Free PMC article.
In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease.
Iannaccone S, Cerami C, Alessio M, Garibotto V, Panzacchi A, Olivieri S, Gelsomino G, Moresco RM, Perani D. Iannaccone S, et al. Parkinsonism Relat Disord. 2013 Jan;19(1):47-52. doi: 10.1016/j.parkreldis.2012.07.002. Epub 2012 Jul 26. Parkinsonism Relat Disord. 2013. PMID: 22841687