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Review
. 2012 May;10 Suppl 2(Suppl 2):s25-38.
doi: 10.2450/2012.006S.

Cell-derived microparticles in stored blood products: innocent-bystanders or effective mediators of post-transfusion reactions?

Anastasios Kriebardis  1 , Marianna Antonelou, Konstantinos Stamoulis, Issidora Papassideri
Affiliations
Review

Cell-derived microparticles in stored blood products: innocent-bystanders or effective mediators of post-transfusion reactions?

Anastasios Kriebardis et al. Blood Transfus. 2012 May.
No abstract available

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Figures

Figure 1
Figure 1
Microparticles (MPs) are inherent part of all blood labile products and are concomitantly delivered by transfusion to recipients. A growing body of literature has demonstrated an increased incidence of adverse clinical outcomes associated with the transfusion of a large number of units or, potentially, with increased storage time of the units. Since MPs accumulate in blood labile products during storage, transfusion of more or “older” units will offer to the recipient higher number of MPs. The transfused MPs have the potential to increase the risk of adverse reactions, by inducing a hypercoagulable state leading to thromboembolic complications. Inversely, in other situations requiring blood transfusion, a hypercoagulable state may be useful to diminish or even helping to stop the bleeding. In both cases, MPs accumulation, cellular origin and composition might be factors of blood labile products quality control.
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