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. 2012 Sep 3;51(36):9057-60.
doi: 10.1002/anie.201202414. Epub 2012 Aug 13.

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms

Nicolas Barraud  1 , Bharat G Kardak, Nageshwar R Yepuri, Robert P Howlin, Jeremy S Webb, Saul N Faust, Staffan Kjelleberg, Scott A Rice, Michael J Kelso
Affiliations

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms

Nicolas Barraud et al. Angew Chem Int Ed Engl. .

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.

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