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Review
. 2012 Jan;8(1):6-12.
doi: 10.14797/mdcj-8-1-6.

Programmable bio-nanochip technology for the diagnosis of cardiovascular disease at the point-of-care

Nicolaos Christodoulides  1 , Floriano N Pierre, Ximena Sanchez, Luanyi Li, Kyle Hocquard, Aaron Patton, Rachna Muldoon, Craig S Miller, Jeffrey L Ebersole, Spencer Redding, Chih-Ko Yeh, Wieslaw B Furmaga, David A Wampler, Biykem Bozkurt, Christie M Ballantyne, John T McDevitt
Affiliations
Review

Programmable bio-nanochip technology for the diagnosis of cardiovascular disease at the point-of-care

Nicolaos Christodoulides et al. Methodist Debakey Cardiovasc J. 2012 Jan.

Erratum in

  • Methodist Debakey Cardiovasc J. 2012 Jul-Sep;8(3):48

Abstract

Cardiovascular disease remains the leading cause of death in the world and continues to serve as the major contributor to healthcare costs. Likewise, there is an ever-increasing need and demand for novel and more efficient diagnostic tools for the early detection of cardiovascular disease, especially at the point-of-care (POC). This article reviews the programmable bio-nanochip (P-BNC) system, a new medical microdevice approach with the capacity to deliver both high performance and reduced cost. This fully integrated, total analysis system leverages microelectronic components, microfabrication techniques, and nanotechnology to noninvasively measure multiple cardiac biomarkers in complex fluids, such as saliva, while offering diagnostic accuracy equal to laboratory-confined reference methods. This article profiles the P-BNC approach, describes its performance in real-world testing of clinical samples, and summarizes new opportunities for medical microdevices in the field of cardiac diagnostics.

Keywords: P-BNC; bio-nanochips; cardiac biomarkers; cardiovascular disease; in vitro diagnostics; lab-on-a-chip technologies; point of care testing; programmable bio-nanochips.

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