Efficacy of memoral herbal on prevention of electroconvulsive therapy-induced memory impairment in mood disorder patients (isfahan - iran 2011)

Abstract

Background: Electroconvulsive therapy (ECT) is one of the most efficacious treatment for major depressive disorder (MDD), it is also used as a rapid and efficacious treatment for other psychiatric disorders, especially treatment resistant ones. The cognitive impairment is one of the most important side effects of ECT. This study examined the Memoral herbal efficacy in prevention of ECT-induced memory impairment.

Methods: In a randomized clinical trial, 70 patients with mood disorders who were candidates for ECT enrolled in either Memoral or Control group, and received either Memoral or placebo. The memory was assessed by Addenbrook Cognitive Examination (ACE), and the findings were analyzed by ANOVA under SPSS18.

Results: The Memoral group patients showed significantly higher total ACE scores than placebo group (P < 0.001). The scores of attention and orientation, verbal fluency and memory subscales not only never decreased during the study in Memoral group, but also increased. There was no significant difference between these scores of Memoral and placebo groups for the subscales of language and visuospacial ability.

Conclusion: The Memoral herbal is an efficacious and safe choice in prevention of ECT- induced cognitive impairment.

Keywords: Cognitive impairment; ECT; Memoral herbal; memory.

Figure 1

The mean of the total score of ACE in Memoral and placebo groups at four assessment occasions :before intervention, before 4^th ECT session, 1month and 2months after last ECT sessions

Figure 2

The mean of the memory subscale score of ACE in Memoral and placebo groups at four assessment occasions: before intervention, before 4^th ECT session, 1month and 2 months after last ECT sessions