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. 2012 Oct;29(7):861-4.
doi: 10.1007/s10585-012-9522-0. Epub 2012 Aug 15.

Biomarkers of cancer metastasis through the lymphovascular system: future perspectives

Stanley P L Leong  1 , Marlys Witte
Affiliations

Biomarkers of cancer metastasis through the lymphovascular system: future perspectives

Stanley P L Leong et al. Clin Exp Metastasis. 2012 Oct.

Abstract

Cancer progression from the primary site to the regional lymph nodes and beyond to the distant sites through the lymphovascular system is genetically determined. In general, sentinel lymph node in the regional lymph nodes is the gateway for metastasis. Biomarkers are becoming increasingly important to define different phases of metastasis. With further understanding of the molecular mechanisms of metastasis, more targets are available for selective therapeutic intervention so that effective therapy can be delivered against cancer in a more personalized approach.

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