[Norovirus (infants/children)]

Abstract

Human norovirus (NoV) is an important cause of the epidemic acute gastroenteritis in children and adults. This review mentions on the required knowledge to understand morphology, genetics, transmission, pathogenesis, and control. The development of molecular diagnostic techniques is clarified the epidemiological impact that is now recognized not only as the major cause of foodborne gastroenteritis outbreaks but also as a cause of sporadic gastroenteritis. It was recognized that the combination pattern to an intestinal epithelium of NoV was prescribed in organization, blood type antigen (histoblood group antigen: HBGA). In children, NoV has various complications especially benign convulsions associated with mild gastroenteritis and associated-encephalopathy. NoV virus-like particle (VLP) vaccine is developing as the protection against acute viral gastroenteritis with a homologous virus.