Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Dec;7(3):226-9.
doi: 10.1016/0920-1211(90)90019-r.

The efficacy and long-term tolerability of lamotrigine in the treatment of severe epilepsy

J W Sander  1 , P C Trevisol-Bittencourt, Y M Hart, P N Patsalos, S D Shorvon
Affiliations

The efficacy and long-term tolerability of lamotrigine in the treatment of severe epilepsy

J W Sander et al. Epilepsy Res. 1990 Dec.

Abstract

We report the effects of the addition of lamotrigine, a novel antiepileptic drug, to the therapy of 125 patients with severe refractory epilepsy. Forty-five patients (36%) reported adverse experiences and in 19 (15%), the drug was withdrawn. The commonest adverse experiences were diplopia, headache, ataxia, drowsiness, skin rash and deterioration in seizure control. Two patients were withdrawn for other reasons. The remaining 104 patients were followed for a mean of 11 months (range 3-27): 26 (25%) of these showed a marked improvement in seizure frequency (a 50% or more reduction when compared with the pre-trial period), but no patient was rendered seizure-free. Tolerance to the effects of the drug was not seen.

PubMed Disclaimer

Publication types