Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2012 Sep 1;11(17):3147-8.
doi: 10.4161/cc.21588. Epub 2012 Aug 16.

Too much or too little: harnessing senescence to control oncogene-driven cancer

Katherine M Hannan, Richard B Pearson
Editorial

Too much or too little: harnessing senescence to control oncogene-driven cancer

Katherine M Hannan et al. Cell Cycle. .
No abstract available

PubMed Disclaimer

Figures

None
Figure 1. Pro-sensecence therapies alone, or in combination with standard therapies, may promote the sensecense “brake” on tumorgenesis.
See this image and copyright information in PMC

Comment in

  • Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene. 2012;31:1949–62. doi: 10.1038/onc.2011.394.

Similar articles

See all similar articles

References

    1. Engelman JA, et al. Nat Med. 2008;14:1351–6. doi: 10.1038/nm.1890. - DOI - PMC - PubMed
    1. Weinstein IB, et al. Nat Clin Pract Oncol. 2006;3:448–57. doi: 10.1038/ncponc0558. - DOI - PubMed
    1. Hanahan D, et al. Cell. 2011;144:646–74. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed
    1. Nardella C, et al. Nat Rev Cancer. 2011;11:503–11. doi: 10.1038/nrc3057. - DOI - PubMed
    1. Astle MV, et al. Oncogene. 2012;31:1949–62. doi: 10.1038/onc.2011.394. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources