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. 2012 Sep;31(9):973-4.
doi: 10.1097/INF.0b013e31825ba6b3.

Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with Kawasaki disease

Seigo Korematsu  1 , Yoko Ohta, Naotaka Tamai, Masahiro Takeguchi, Chika Goto, Hiroaki Miyahara, Tatsuya Kawano, Tatsuro Izumi
Affiliations

Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with Kawasaki disease

Seigo Korematsu et al. Pediatr Infect Dis J. 2012 Sep.

Abstract

The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.

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