Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Sep;13(9):543-7.
doi: 10.1038/nrm3417. Epub 2012 Aug 16.

The super elongation complex (SEC) family in transcriptional control

Zhuojuan Luo  1 , Chengqi Lin, Ali Shilatifard
Affiliations
Review

The super elongation complex (SEC) family in transcriptional control

Zhuojuan Luo et al. Nat Rev Mol Cell Biol. 2012 Sep.

Abstract

The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. It is one of the most active P-TEFb-containing complexes required for rapid transcriptional induction in the presence or absence of paused Pol II. The SEC was found to regulate the transcriptional elongation checkpoint control (TECC) stage of transcription, and misregulation of this stage is associated with cancer pathogenesis. Recent studies have shown that the SEC belongs to a larger family of SEC-like complexes, which includes SEC-L2 and SEC-L3, each with distinct gene target specificities.

PubMed Disclaimer

References

    1. Science. 2009 Jul 24;325(5939):471-3 - PubMed
    1. Mol Cell. 2010 Feb 12;37(3):429-37 - PubMed
    1. Cancer Res. 2007 Nov 15;67(22):10677-85 - PubMed
    1. Nature. 2011 Oct 02;478(7370):529-33 - PubMed
    1. Genes Dev. 2008 Oct 15;22(20):2755-66 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources