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Review
. 2012:12:14.
Epub 2012 May 1.

Monoclonal antibodies in cancer therapy

Andrew M Scott  1 , James P Allison, Jedd D Wolchok
Affiliations
Review

Monoclonal antibodies in cancer therapy

Andrew M Scott et al. Cancer Immun. 2012.
No abstract available

Keywords: antibody identification; antigenic targets; tumor surface antigens; tumor therapy.

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Figures

Figure 1
Figure 1
Biodistribution of 131I-huA33 in a patient with metastatic colorectal carcinoma. Anterior whole body gamma camera images are shown following infusion of 131I-huA33 at (A) day 0, (B) day 1, and (C) day 5. A standard for quantitation of 131I-huA33 uptake is present, adjacent to the left shoulder. Initial (day 0) images (A) show blood pool appearance only, with large metastatic lesions in the liver demonstrating an initial hypovascular appearance. (B) Excellent targeting of the metastatic lesions in the liver by 131I-huA33 is clearly seen (arrow) as early as day 1, and increasing rapidly with time to day 5. Some central necrosis in the larger tumors is also evident (arrow), also seen on CT scan (D). Gradual bowel uptake (double arrow) of 131I-huA33 is also seen, which gradually decreases with time. No other normal tissue uptake of 131I-huA33 is evident.
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