Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May 1;5(3):291-3.
doi: 10.4161/cib.19914.

The unexpected role of Drosophila OCRL during cytokinesis

Khaled Ben El Kadhi, Grégory Emery, Sebastien Carreno

The unexpected role of Drosophila OCRL during cytokinesis

Khaled Ben El Kadhi et al. Commun Integr Biol. .

Abstract

Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that the Drosophila inositol 5-phosphatase, dOCRL, is essential for cytokinesis, the last step of cell division (Ben El Kadhi et al. 2011).(8) We demonstrated that dOCRL is required for the dephosphorylation of PtdIns(4,5)P(2) at the surface of endosomes, resulting in the restriction of this phosphoinositide to the cell cortex during cytokinesis. dOCRL is the Drosophila ortholog of human OCRL1, a PtdIns(4,5)P(2) phosphatase mutated in the X-linked disorder oculocerebrorenal Lowe syndrome. Here, we discuss the relevance of our findings with reference to the role of human OCRL1 in non-pathological and pathological conditions.

Keywords: Lowe syndrome; OCRL1; PtdIns(4,5)P2; cell division; cytokinesis; intracellular trafficking; phosphoinositides.

PubMed Disclaimer

Comment on

  • Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno S. The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis. Curr Biol. 2011;21:1074–9. doi: 10.1016/j.cub.2011.05.030.

References

    1. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006;443:651–7. doi: 10.1038/nature05185. - DOI - PubMed
    1. Vicinanza M, D’Angelo G, Di Campli A, De Matteis MA. Function and dysfunction of the PI system in membrane trafficking. EMBO J. 2008;27:2457–70. doi: 10.1038/emboj.2008.169. - DOI - PMC - PubMed
    1. Kutateladze TG. Translation of the phosphoinositide code by PI effectors. Nat Chem Biol. 2010;6:507–13. doi: 10.1038/nchembio.390. - DOI - PMC - PubMed
    1. Emoto K, Inadome H, Kanaho Y, Narumiya S, Umeda M. Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. J Biol Chem. 2005;280:37901–7. doi: 10.1074/jbc.M504282200. - DOI - PubMed
    1. Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, et al. PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Curr Biol. 2005;15:1407–12. doi: 10.1016/j.cub.2005.06.059. - DOI - PubMed

LinkOut - more resources