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Comment
. 2012 Aug 14;22(2):141-2.
doi: 10.1016/j.ccr.2012.07.018.

Burkitt lymphoma: much more than MYC

David Dominguez-Sola  1 , Riccardo Dalla-Favera
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Free article
Comment

Burkitt lymphoma: much more than MYC

David Dominguez-Sola et al. Cancer Cell. .
Free article

Abstract

Chromosomal translocations causing deregulated c-MYC expression are detectable in most Burkitt lymphoma cases. However, little is known about the additional lesions necessary for lymphomagenesis. Now, two independent studies, one of which was performed by Sander et al. in this issue of Cancer Cell, identify constitutive PI3K signaling and CyclinD3 mutations as cooperating lesions in both mice and humans. The results have directly actionable therapeutic implications.

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  • Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
    Sander S, Calado DP, Srinivasan L, Köchert K, Zhang B, Rosolowski M, Rodig SJ, Holzmann K, Stilgenbauer S, Siebert R, Bullinger L, Rajewsky K. Sander S, et al. Cancer Cell. 2012 Aug 14;22(2):167-79. doi: 10.1016/j.ccr.2012.06.012. Cancer Cell. 2012. PMID: 22897848 Free PMC article.

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