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. 2012 Aug 16;9(1):75.
doi: 10.1186/1743-7075-9-75.

The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism

Xian-Cheng Jiang  1 , Weijun Jin, Mahmood M Hussain
Affiliations

The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism

Xian-Cheng Jiang et al. Nutr Metab (Lond). .

Abstract

It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. In mouse models, it has been demonstrated that PLTP overexpression induces atherosclerosis, while its deficiency reduces it. PLTP is considered a promising target for pharmacological intervention to treat atherosclerosis. However, we must still answer a number of questions before its pharmaceutical potential can be fully explored. In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism.

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